Granted. The Monkey’s Paw is now replaced by an alternative wishing mechanism that is slightly more evil- it had previously been wished out of existence by the Paw, you see.

Granted, monkeys never evolved. One monkeys hand was never severed and cursed. A different species took its place in its ecological niche. A large lizard gets its appendage cut off and cursed.

You come into possession of a cursed lizard claw that grants you 4 wishes.

The entire universe ends.