Every engine from the S38B38 onwards except for the S52 has premature rod bearing wear issues due to tight clearances. And no that’s why I don’t think the S65 can be considered “reliable if maintained.” Let’s not kid ourselves, these are high maintenance cars.
Plenty of cars do perfectly fine with bone stock bearings past 200,000, even older M cars. Trying to downplay rod bearing replacement as not a major job is peak copium.
If you had a well-made V12 like a Mercedes M120 then yes it should be as easy to maintain. You’ve just been desensitized and accustomed to overly complex engines.