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Cake day: June 12th, 2023

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  • It has a part that is embedded in a mitochondrial membrane and works as a rotor. The other part is sticking out from the membrane and is responsible for synthesis of ATP from ADP and phosphate. An off-axis part of the rotor pushes the stator, it changes shape and pushes ADP and phosphate together, until they fuse to ATP.

    To make the rotor move, it makes use of membrane potential. One side of the membrane has a lot more H⁺ (just protons, really) than the other. The excess H⁺ want to go to the other side. The membrane doesn’t let them through. It is hydrophobic on the inside, so it does’t let through anything charged (like H⁺) or polar (like water). This is the potential and it has quite a lot of energy. ATP synthase lets the H⁺ through by binding them to the rotor in the membrane in a particular place and releases them in another in such a way that forces the rotor to turn almost a full turn before they can leave and stops it from rotating the other way. As mentioned, the rotation is transfered to the stator, changing its shape and thus creating ATP. As a side note, multiple H⁺ are bound on the rotor along its circumference, so each rotation is powered by the potential energy of multiple protons.

    Of course, it’s a bit more complicated than that, but I don’t think there’s anything downright wrong or misleading in what I wrote. I hope I managed to make it understandable. Also, I recommend animations of the synthase on youtube.


  • That’s the case for most species.

    As a very specific and highly functional example of critical viral proteins in other organisms, there wouldn’t be any placental mammals without viruses. https://en.m.wikipedia.org/wiki/Placenta

    Mammalian placentas probably first evolved about 150 million to 200 million years ago. The protein syncytin, found in the outer barrier of the placenta (the syncytiotrophoblast) between mother and fetus, has a certain RNA signature in its genome that has led to the hypothesis that it originated from an ancient retrovirus: essentially a virus that helped pave the transition from egg-laying to live-birth.


  • I don’t, Musk is too influential. And honestly, I don’t think there needs to be much concern about space launch part of the business. I’m under the impression that it is already regulated enough to be relatively safely under control. And I would be sad to see it taken away from SpaceX and probably even Musk specifically. He is an incredible idiot and dangerous person, but the progress they did and triggered in others is undeniable and I’d like to see it continue.

    But Starlink is a completely different matter. Private company strongly lead by a single, somewhat crazy person, is very dangerous. I think few people expected it to be such a game changer in the beginning, I certainly didn’t. But it is important and very influential. Maybe ideal would be if it was controlled by the government, if it had the final say in geopolitical decisions etc., but the profits (or some part), development and such remained in the hands of SpaceX. Well, some international body as isolated from political influence as possible would be even better, but there’s no chance of that happening.
















  • I relatively often meet 4 of these:

    • no speed limit (use the normal limit for this type of road)

    • car tires may defy laws of nature (slippery road, usually followed by a sign saying it applies during rain)

    • speed camera ahead

    • no water polluting goods (not very common, but occasionally comes up. There is also no dangerous materials with an orange trapezoid instead of an ellipse)

    I also saw don’t drive off the pier (around ferries), watch for skiers (in the mountains with cross-country skiing routes), and warning about planes, although in different design (around airports).