By now it is probably no longer news to many: GNOME Shell moved from GJS’ own custom imports system to standard JavaScript modules (ESM).
Extensions that target older GNOME versions will not work in GNOME 45. Likewise, extensions that are adapted to work with GNOME 45 will not work in older versions.
You can still support more than one GNOME version, but you will have to upload different versions to extensions.gnome.org for pre- and post-45 support.
Please file bugs with your favorite extensions or have a friendly conversation with your extension writers so that we can help minimize the impact of this change. Ideally, you could help with the port and provide a pull or merge request to help maintainers.
See, this is the beauty of running Debian stable as your daily driver. I’ll be on Gnome 43 for two more years, so by the time I upgrade to Gnome 45+ extensions should be compatible. Only half-joking, I really do avoid a lot of early adopter regressions and breakage.
Arch does too, albeit to a lesser extent. Gnome updates usually take around 4 to 5 weeks after the official release to hit the Pacman repos.
Means you can stay bleeding edge but avoid day 1 breakages for the most part.
Is there a distro that ships with the latest kernel and gnome packages?
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Opensuse Tumbleweed.