The engineering of artificial cells requires a reconfigurable cytoskeleton that can organize at distinct locations and dynamically modulate its structural and mechanical properties. This study combines peptide self-assembly with DNA programmability to realize a synthetic cytoskeleton in droplets showing that programmable peptide–DNA nanotechnology approach is a powerful platform towards the construction of functional, fully artificial cells.
https://www.nature.com/articles/s41557-024-01509-w (open access)
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I know no microscopic biology but I imagine other natural cells encountering such a cell and recoiling from it the same way dogs who sniff a robot dog and sense nothing are legit highly freaked out 😂
Uncanny valley but for cells.